| steectaps | Дата: Воскресенье, 22.12.2013, 17:59 | Сообщение # 1 |
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Статус:  | Simvastatin is a substrate for CYP3A4 (see [#section-7.3 PRECAUTIONS, Drug Interactions - ). Grapefruit juice contains one or more components that inhibit CYP3A4 and can increase the plasma concentrations of drugs metabolized by CYP3A4. In one study[#footnote-2 2 - , 10 subjects consumed 200 mL of double-strength grapefruit juice (one can of frozen concentrate diluted with one rather than 3 cans of water) three times daily for 2 days and an additional 200 mL double-strength grapefruit juice together with, and 30 and 90 minutes following, a single dose of 60 mg simvastatin on the third day.
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The white blood cells are an important component of the immune system which fights against infections and inflammation in the body.
There are data suggesting that a vascular lesion plus prothrombotic risk factors predict recurrence risk.
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