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Статус:  | Sodium oxybate was not carcinogenic in rats administered oral doses of up to 1000В mg/kg/day (2В times the exposure in humans receiving the maximum recommended dose (MRHD) of 9В g/day, on an AUC basis) for 83В weeks in the male rats and for 104В weeks in female rats.
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Routine follow-up is recommended for patients with metabolic syndrome, both to address the treatment of the components present, as well as to monitor for the development of heart disease or associated problems.
The most prominent pathway involves direct conjugation at the phenolic hydroxyl group.
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